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On 01/03/2018 I joined UCL and Moorefields as a research assistant. I have specialized in adaptive optics. Using this method we can acquire high resolution images of the retina of humans in vivo. At this magnification individual photoreceptors are discernible and the smallest blood vessels can be measured. Below you can see a model of a human eye to help you with grasp the scale of adaptive optics imaging systems.

Furthermore, you can see some of raw data from the microscope here:

Our interests revolve around applying this type of imaging to  clinical studies looking into retinal degenerative diseases such as Ucher and Choroideremia. Furthermore, we are working with methods to measure blood flow in small vessels of the eye to investigate the vascular component of multiple sclerosis. My main tasks involve maintaining the adaptive optics scanning laser ophthalmoscope running, acquiring and processing the data and developing or adapting tools to streamline the process. Furthermore, I have enjoyed taking up extra projects such as : using a microcontroller to record signals from a pulse oximeter, writing code to automatically align and focus stack images, formatting data from commercial instruments to assist clinicians, helping with segmenting and 3d printing models from micro-CT data, and repairing devices around the institute of ophthalmology such as stereo microscopes. Last but not least, I have pursued my passion for science communication by joining all the events of our institute(ex. Barts and Queen Mary Science Festival), creating new demos and volunteering with the institute of making.

Disgust and delight
Public engagement with the institute of making.

Pulse oximeter data extraction

For our work on measuring blood flow at the smallest vessels in the retina a pulse oximeter was purchased (Radical 7, Masimo) . This oximeter has an API which can be used to get a few parameters such as oxygenation or heart rate.  There is no way to get the plethysmogram (curve corresponding to heart activity based on oxygenation). This was required in order to assist the work of a phd student in our lab. Masimo provides a repair manual for their instrument. There it is mentioned that there is a serial port which transmits the signal of interest. A 3£ micro-controller was used to digitize the signal. A serial port reader was used to record and save data CoolTerm

Plethysmogram on serial monitor

easter egg
Easter egg